Eat Happy
October 11, 2025

The “Antidepressant Diet”: What Science Says About Food and Mood

Can what you eat really influence your mood? According to research published in the World Journal of Psychiatry (LaChance & Ramsey, 2018), the answer is yes to a meaningful extent.  The study set out to identify foods that are richest in nutrients known to support mental health. From a review of dozens of studies, researchers pinpointed 12 key nutrients that appear most linked to lower rates of depression and better emotional wellbeing.


The 12 “Antidepressant Nutrients”

These include folate, iron, long-chain omega-3 fatty acids (EPA & DHA), magnesium, potassium, selenium, thiamine (B1), vitamins A, B6, B12, C, and zinc.  Each of these plays a role in brain health — from neurotransmitter function and inflammation control to energy metabolism.


Foods That Scored Highest

The researchers then created an Antidepressant Food Score (AFS) to rank foods by how nutrient-dense they are in those 12 areas.
Top-scoring foods included:

  • Seafood — especially oysters, mussels, and other bivalves
  • Organ meats — like liver and kidney
  • Leafy greens — spinach, kale, romaine
  • Cruciferous vegetables — broccoli, Brussels sprouts, cauliflower
  • Peppers, herbs, and citrus fruits - think watercress!

Interestingly, vegetables scored highest overall, followed by organ meats and seafood.


What This Means for Everyday Eating

The “antidepressant diet” isn’t a strict plan — it’s a guide toward eating in a way that supports your mental health.
You can put it into practice by:

  • Eating more colourful vegetables and leafy greens
  • Including fish or seafood several times per week
  • Getting a variety of nutrient-rich whole foods
  • Limiting ultra-processed and sugary foods


While diet alone is not the only thing that can influence depression, improving nutrition is one of the most accessible ways to support brain function and emotional wellbeing.  We say dig into those oysters ... yum!

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